Ok how many of you have actually killed something out there in the real world? I'm talking anything from mice, birds to bears, elk, deer or even a human. I'm new to the internet world and have read and seen a ton of posts on the subject. Most are wrong or flawed. The squierrel killed by a .45 was the straw that broke the proverbial straw. I loved it a .45 was used and a good shot was made for sure so it has nothing to do with him. This is not bragging on my part as I should have way more trophys on the wall than I do, but I have killed at least 175 deer sized animals or more. I have guided or been around at least twice that many. I guess what I'm saying is the .45 is ok as a defense weapon because I can't carry a.220 swift. That rodent would have been blown into little peices if it had been hit with .220. 22-250, or a .204. Most of the deer I have shot 65% or so ran 30-100 yds. after a killing shot was delivered. The .45 has proven itself in combat I know and is what I pack. 1,000 lbs of energy is considered the minimum that should be used to kill a deer at any range and the .45 isn't even close to that at the muzzle. I sure don't want to be shot with a .45 or the lowly .22 for that matter. I just wonder what you guys think a .45 is gonna do. Most likely kill ya I know but I have seen some weird things and some animals that were shot multiple times with guns way more powerful than a .45 before they expired. Hydostatic shock is something I believe in big time and is why I pack a .270 with 130 gr. soft points. The .45 has limited shock compared to that. I have lots of bullets including a .45 dug out of animals. All pistol rds are marginal defense rds as far as my personal experience has shown. But then ANY GUN GOOD SHOOT"EM GOOD.