Big believer in Federal HST - 230gr Std pressure in .45 and 147gr in 9mm. I looked at every ballistic test available, and have shot a variety of critters with them and they just plain perform as advertised. Of course, good performance ammo gives a small edge, but SHOT PLACEMENT is 90% of the equation. I think we tend to overthink and dwell on bullet type. A hit to the brain-housing unit will do the trick regardless of the bullet type.