I think you answered your own question. TX22, either the standard or compact.
Ronald Reagan was nearly taken out with 1 22lr in the armpit.
If your wife can get half a magazine's worth of 22s into center mass I think you have a winner.
I have my various HD guns but in reality, I know I could put 10 22s into the face of a threat with my S&W 22 Victory. Keeping a 22 reliable really is not that hard.
Ronald Reagan was nearly taken out with 1 22lr in the armpit.
If your wife can get half a magazine's worth of 22s into center mass I think you have a winner.
I have my various HD guns but in reality, I know I could put 10 22s into the face of a threat with my S&W 22 Victory. Keeping a 22 reliable really is not that hard.