My wife loves shooting .22 pistols and rifles. She is a bit uneasy about larger calibers when we shoot at the range. I know that if her life or the kids like depended on it she would have zero issues using a LCP or something like that, but she would be more comfortable with a .22 pistol. That being said would you feel comfortable knowing that your wife was going to have to defend herself with a .22 god forbid the need should arise? I know it isn't the optimal caliber, but I am a firm believer in that you should be comfortable with the firearm you are going to carry. Thanks in advance guys.